In recent months, NAD plus supplements have surged in popularity, particularly on social media platforms, where they are touted for their potential to 'reverse' the aging process. This trend raises an important question: how much of this is backed by scientific evidence?

NAD plus, or nicotinamide adenine dinucleotide, is a vital molecule present in every living cell of the body. It plays a crucial role in maintaining youthful skin and overall bodily functions. As we age, however, our natural levels of NAD plus decline, leading to various signs of aging, including decreased energy and skin elasticity. This decline is precisely why many believe that taking NAD plus supplements could serve as a remedy to counteract these age-related changes.

Despite the growing interest and anecdotal reports suggesting benefits, the effectiveness of NAD plus supplements remains a subject of debate. To gain a clearer understanding of this emerging trend, we consulted several medical professionals and experts who offered insights into what NAD plus is, how these supplements might function in terms of anti-aging, and whether they are safe for everyday use.

Products like TruNiagen and its sister supplement Tru Niagen Pro claim to enhance cognitive function, increase energy levels, improve metabolism, support cardiovascular health, and slow the aging process. While they seem promising, experts emphasize that research on these supplements is still in its early stages, and further investigation is necessary to ascertain their long-term effects. The price for these supplements varies, with TruNiagen retailing for approximately $116 and similar products available for around $113 on platforms like Amazon.

Understanding NAD Plus and Its Role in the Body

Dr. Konstantin Vasyukevich, a facial plastic surgeon based in New York, describes NAD plus as a coenzyme essential for maintaining cellular functionality. It facilitates energy production, assists in DNA repair, and regulates circadian rhythms. According to Dr. Nayan Patel, a pharmacist and founder of Auro Wellness, NAD plus is integral to the function of sirtuins, which are proteins that manage cell survival and aging processes.

NAD plus is not to be confused with NADH, despite their related names. While NAD plus is in an oxidized state, NADH is reduced, meaning NAD plus possesses an extra electron that it releases to become NADH. As individuals age, the natural decline of NAD plus levels can contribute to feelings of fatigue and visible skin aging, which is where supplements come into play. Additionally, vitamin B3 (niacin) acts as a precursor to NAD plus, meaning that it can also elevate NAD plus levels when ingested.

The Benefits of NAD Plus

One of the most significant advantages of NAD plus supplements is their potential to act as an energy enhancer. Scientific studies, including recent research from 2023, have demonstrated that this coenzyme can assist in weight management while also helping to regulate metabolism. Dr. Vasyukevich notes that NAD plus offers several benefits: "It promotes DNA repair and combats oxidative stress, which are major contributors to skin aging. It also aids cellular production of adenosine triphosphate (ATP), the primary energy carrier in all living organisms."

Potential Side Effects of NAD Plus Supplements

While many experts regard NAD plus supplements as generally safe, Dr. Jonathan Jennings, a board-certified internist with Medical Offices of Manhattan, advises caution. The FDA does not regulate dietary supplements in the same manner as medications, so users should be aware of potential side effects. Common adverse reactions reported include abdominal pain, nausea, dizziness, and flushing.

Moreover, Dr. Vasyukevich warns that taking NAD plus supplements late in the day could disrupt sleep patterns, though adjusting the timing of intake could usually resolve this issue. Both Dr. Jennings and Dr. Patel stress the importance of consulting a healthcare provider before beginning any supplement regimen and suggest that individuals cease taking the supplement if they experience any adverse reactions.

Who Should Avoid NAD Plus Supplements?

Despite their general safety, NAD plus supplements may not be suitable for everyone. Dr. Jennings emphasizes the necessity of consulting a healthcare professional, particularly for vulnerable populations such as pregnant individuals and children. Dr. Patel also advises nursing mothers to err on the side of caution, as there is insufficient research on the safety of these supplements for such groups.

Individuals with pre-existing liver or kidney conditions should exercise particular caution, given how the body metabolizes NAD plus. Factors such as age, genetics, diet, and overall health can significantly influence how effectively a person responds to supplementation.

Can NAD Plus Supplements Truly Slow Down Aging?

While many experts assert that NAD plus supplements may have beneficial effects, they caution against viewing them as a panacea for aging. Dr. Vasyukevich remarks that these supplements can indeed support the bodys repair mechanisms, potentially leading to a reduction in visible signs of aging. However, he stresses that they are not a miraculous solution for halting the aging process entirely.

Dr. Patel echoes this sentiment, stating that while preliminary studies indicate potential benefits for energy levels and skin health, further clinical trials are essential to establish their effectiveness in aging prevention. He also emphasizes that these supplements should not replace healthy lifestyle choices, such as regular exercise, balanced nutrition, adequate sleep, and effective stress management, which are critical for maintaining overall well-being as one ages.

Proper Dosing and Administration of NAD Plus Supplements

NAD plus can be supplemented in various forms, including oral, nasal, intramuscular, and intravenous methods. The effectiveness of these methods and appropriate dosages is still being investigated. Nicotinamide riboside and nicotinamide mononucleotide, both NAD plus precursors, have shown promise in improving age-related health, but caution is advised.

A recent study on these precursors indicated improvements in cardiovascular, metabolic, and physical functions among participants across different dosage regimens. However, the optimal dosage is highly individual and should be discussed with a healthcare provider. Generally, oral or nasal forms can be taken daily, but professional guidance is crucial for safety and effectiveness.

Alternative Methods to Boost NAD Plus Levels

Increasing NAD plus levels does not solely rely on supplementation. In fact, healthcare experts advocate for a comprehensive approach to health that includes lifestyle changes to bolster the effectiveness of any supplements. Regular physical activity, intermittent fasting, and caloric restriction are all natural methods to enhance NAD plus production within the body.

Dr. Vasyukevich notes that routine exercise can stimulate the generation of NAD plus precursors, while Dr. Patel emphasizes that maintaining good sleep hygiene and managing stress can also positively influence NAD plus levels. Additionally, dietary choices play a significant role; consuming foods high in vitamin B3 and niacin can further enhance the body's NAD plus production. Foods rich in these nutrients include:

  • Beef
  • Broccoli
  • Cabbage
  • Dairy products
  • Fish
  • Fruit
  • Nuts
  • Peanuts
  • Seeds
  • Turkey
  • Whole grains

The Bottom Line

As we age, the natural decline in NAD plus levels can contribute to fatigue and skin aging. However, a combination of a healthy lifestyleincluding regular exercise, a diet enriched with vitamin B3 and niacin, and, if appropriate, NAD plus supplementation under medical supervisioncan help mitigate these effects. While research on NAD plus supplements is still developing, medical professionals recommend maintaining a cautious approach and always consulting with a healthcare provider before starting any new supplement regimen.