Ever thought a simple shot could change your life? That's exactly what Rosie O'Donnell is experiencing as she revels in her incredible weight loss journey thanks to the medication Mounjaro. The beloved former talk show host, now 63, has been on this weight loss drug since late 2022, and she's still in disbelief over the transformation she has undergone.

In a heartfelt Instagram post, Rosie shared her excitement about fitting into a size 12, exclaiming, ‘#Mounjaro is a life saver!’ as she flaunted her new look while shopping for comfortable travel wear for her upcoming 22-hour flight to Australia. Sporting a fitted black tracksuit that hugged her slimmer figure, she captured the moment in a dressing room with her friends Cam and Robin. She candidly remarked, ‘I can't believe I’m a size 12!’

The comments section exploded with admiration and joy from her fans, with one follower simply writing, ‘WOW!’ adorned with emojis, while fellow celebrity Kristin Chenoweth chimed in, ‘You look amazing!’ Others echoed their excitement, noting how Mounjaro not only promotes weight loss but also alleviates inflammation, contributing to an overall feeling of wellness.

Rosie's journey is not just about the numbers on the scale. Back in March, she opened up about her shocking transformation, revealing in a TikTok video that her new size came alongside a busy lifestyle that included cooking for her son, Clay, after a two-year stint with a personal chef. ‘I find it completely shocking,’ she said, reflecting on her newfound size after years of wearing larger clothes.

Taking Mounjaro has not only helped Rosie shed pounds but has also improved her overall health, giving her better sleep quality and more energy. Earlier this year, she revealed that she lost 10 pounds during the holiday season, attributing her success to both the medication and her commitment to healthier eating habits, like cutting down on sugary drinks.

As she continues to document her progress, Rosie’s fans remain in awe of her determination and transformation. In a recent post showcasing her stand-up comedy routine, she expressed disbelief at her new physique, saying, ‘I can’t believe this is me now!’ It's a journey that resonates with many, and Rosie’s candidness about her struggles with body image highlights the importance of self-acceptance at any stage of life.